A mechanistic role for leptin in human dendritic cell migration: differences between ileum and colon in health and Crohn's disease

Dendritic cells (DC) migrate to lymph nodes on expression of C-C motif chemokine receptor 7 (CCR7) and control immune activity. Leptin, an immunomodulatory adipokine, functions via leptin receptors, signaling via the long isoform of receptor, LepRb. Leptin promotes DC maturation and increases CCR7 e...

Descripción completa

Detalles Bibliográficos
Autores principales: Al-Hassi, H O, Bernardo, D, Murugananthan, A U, Mann, E R, English, N R, Jones, A, Kamm, M A, Arebi, N, Hart, A L, Blakemore, A I F, Stagg, A J, Knight, S C
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3684777/
https://www.ncbi.nlm.nih.gov/pubmed/23168838
http://dx.doi.org/10.1038/mi.2012.113

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3684777/
https://www.ncbi.nlm.nih.gov/pubmed/23168838
http://dx.doi.org/10.1038/mi.2012.113

Ejemplares similares