Cargando…

The membrane-topogenic vectorial behaviour of Nrf1 controls its post-translational modification and transactivation activity

The integral membrane-bound Nrf1 transcription factor fulfils important functions in maintaining cellular homeostasis and organ integrity, but how it is controlled vectorially is unknown. Herein, creative use of Gal4-based reporter assays with protease protection assays (GRAPPA), and double fluoresc...

Descripción completa

Detalles Bibliográficos
Autores principales: Zhang, Yiguo, Hayes, John D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3684815/
https://www.ncbi.nlm.nih.gov/pubmed/23774320
http://dx.doi.org/10.1038/srep02006