A Short Hairpin RNA Screen of Interferon-Stimulated Genes Identifies a Novel Negative Regulator of the Cellular Antiviral Response

The type I interferon (IFN) signaling pathway restricts infection of many divergent families of RNA and DNA viruses by inducing hundreds of IFN-stimulated genes (ISGs), some of which have direct antiviral activity. We screened 813 short hairpin RNA (shRNA) constructs targeting 245 human ISGs using a...

Descripción completa

Detalles Bibliográficos
Autores principales: Li, Jianqing, Ding, Steve C., Cho, Hyelim, Chung, Brian C., Gale, Michael, Chanda, Sumit K., Diamond, Michael S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Microbiology 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3684836/
https://www.ncbi.nlm.nih.gov/pubmed/23781071
http://dx.doi.org/10.1128/mBio.00385-13

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3684836/
https://www.ncbi.nlm.nih.gov/pubmed/23781071
http://dx.doi.org/10.1128/mBio.00385-13

Ejemplares similares