Cargando…

The Branch-Site Test of Positive Selection Is Surprisingly Robust but Lacks Power under Synonymous Substitution Saturation and Variation in GC

Positive selection is widely estimated from protein coding sequence alignments by the nonsynonymous-to-synonymous ratio ω. Increasingly elaborate codon models are used in a likelihood framework for this estimation. Although there is widespread concern about the robustness of the estimation of the ω...

Descripción completa

Detalles Bibliográficos
Autores principales: Gharib, Walid H., Robinson-Rechavi, Marc
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3684852/
https://www.ncbi.nlm.nih.gov/pubmed/23558341
http://dx.doi.org/10.1093/molbev/mst062