Activation of IP(3) receptors requires an endogenous 1-8-14 calmodulin-binding motif

Binding of IP(3) (inositol 1,4,5-trisphosphate) to the IP(3)-binding core (residues 224–604) of IP(3)Rs (IP(3) receptors) initiates opening of these ubiquitous intracellular Ca(2+) channels. The mechanisms are unresolved, but require conformational changes to pass through the suppressor domain (resi...

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Detalles Bibliográficos
Autores principales: Sun, Yi, Rossi, Ana M., Rahman, Taufiq, Taylor, Colin W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Portland Press Ltd. 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3685217/
https://www.ncbi.nlm.nih.gov/pubmed/23009366
http://dx.doi.org/10.1042/BJ20121034

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3685217/
https://www.ncbi.nlm.nih.gov/pubmed/23009366
http://dx.doi.org/10.1042/BJ20121034

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