The anti-inflammatory drug BAY 11-7082 suppresses the MyD88-dependent signalling network by targeting the ubiquitin system

The compound BAY 11-7082 inhibits IκBα [inhibitor of NF-κB (nuclear factor κB)α] phosphorylation in cells and has been used to implicate the canonical IKKs (IκB kinases) and NF-κB in >350 publications. In the present study we report that BAY 11-7082 does not inhibit the IKKs, but suppresses their...

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Detalles Bibliográficos
Autores principales: Strickson, Sam, Campbell, David G., Emmerich, Christoph H., Knebel, Axel, Plater, Lorna, Ritorto, Maria Stella, Shpiro, Natalia, Cohen, Philip
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Portland Press Ltd. 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3685219/
https://www.ncbi.nlm.nih.gov/pubmed/23441730
http://dx.doi.org/10.1042/BJ20121651

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3685219/
https://www.ncbi.nlm.nih.gov/pubmed/23441730
http://dx.doi.org/10.1042/BJ20121651

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