Efficacy of RNA polymerase II inhibitors in targeting dormant leukaemia cells

BACKGROUND: Dormant cells are characterised by low RNA synthesis. In contrast, cancer cells can be addicted to high RNA synthesis, including synthesis of survival molecules. We hypothesised that dormant cancer cells, already low in RNA, might be sensitive to apoptosis induced by RNA Polymerase II (R...

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Detalles Bibliográficos
Autores principales: Pallis, Monica, Burrows, Francis, Whittall, Abigail, Boddy, Nicholas, Seedhouse, Claire, Russell, Nigel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3685571/
https://www.ncbi.nlm.nih.gov/pubmed/23767415
http://dx.doi.org/10.1186/2050-6511-14-32

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3685571/
https://www.ncbi.nlm.nih.gov/pubmed/23767415
http://dx.doi.org/10.1186/2050-6511-14-32

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