Liver-specific microRNA-122 target sequences incorporated in AAV vectors efficiently inhibits transgene expression in the liver

Vectors based on adeno-associated virus (AAV) are effective in gene delivery in vivo. Tissue-specific gene expression is often needed to minimize ectopic expression in unintended cells and undesirable consequences. Here we investigated if incorporation of target sequences of tissue-specific microRNA...

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Detalles Bibliográficos
Autores principales: Qiao, Chunping, Yuan, Zhenhua, Li, Jianbin, He, Bo, Zheng, Hui, Mayer, Christina, Li, Juan, Xiao, Xiao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2010
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3686499/
https://www.ncbi.nlm.nih.gov/pubmed/21150938
http://dx.doi.org/10.1038/gt.2010.157

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3686499/
https://www.ncbi.nlm.nih.gov/pubmed/21150938
http://dx.doi.org/10.1038/gt.2010.157

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