Pharmacologic Approach to Defective Protein Trafficking in the E637K-hERG Mutant with PD-118057 and Thapsigargin

BACKGROUND: Treatment of LQT2 is inadequate. Many drugs which can pharmacologically rescue defective protein trafficking in LQT2 also result in potent blockade of HERG current, negating their therapeutic benefit. It is reported that PD-118057 and thapsigargin can rescue LQT2 without hERG channel blo...

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Detalles Bibliográficos
Autores principales: Mao, Haiyan, Lu, Xiaoli, Karush, Justin Michael, Huang, Xiaoyan, Yang, Xi, Ba, Yanna, Wang, Ying, Liu, Ningsheng, Zhou, Jianqing, Lian, Jiangfang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3686757/
https://www.ncbi.nlm.nih.gov/pubmed/23840331
http://dx.doi.org/10.1371/journal.pone.0065481

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3686757/
https://www.ncbi.nlm.nih.gov/pubmed/23840331
http://dx.doi.org/10.1371/journal.pone.0065481

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