Functional Role of mTORC2 versus Integrin-Linked Kinase in Mediating Ser473-Akt Phosphorylation in PTEN-Negative Prostate and Breast Cancer Cell Lines

Although the rictor-mTOR complex (mTORC2) has been shown to act as phosphoinositide-dependent kinase (PDK)2 in many cell types, other kinases have also been implicated in mediating Ser473-Akt phosphorylation. Here, we demonstrated the cell line specificity of integrin-linked kinase (ILK) versus mTOR...

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Detalles Bibliográficos
Autores principales: Lee, Su-Lin, Chou, Chih-Chien, Chuang, Hsiao-Ching, Hsu, En-Chi, Chiu, Po-Chen, Kulp, Samuel K., Byrd, John C., Chen, Ching-Shih
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3686768/
https://www.ncbi.nlm.nih.gov/pubmed/23840605
http://dx.doi.org/10.1371/journal.pone.0067149

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3686768/
https://www.ncbi.nlm.nih.gov/pubmed/23840605
http://dx.doi.org/10.1371/journal.pone.0067149

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