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Bax and Bak have critical roles in ischemic acute kidney injury in global and proximal tubule-specific knockout mouse models

Bax and Bak, two pro-apoptotic Bcl-2 family proteins, have been implicated in acute kidney injury following renal ischemia/reperfusion; however, definitive evidence for a role of these genes in the disease process is lacking. Here we first examined two Bax-deficient mouse models and found that only...

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Detalles Bibliográficos
Autores principales: Wei, Qingqing, Dong, Guie, Chen, Jian-Kang, Ramesh, Ganesan, Dong, Zheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3686831/
https://www.ncbi.nlm.nih.gov/pubmed/23466994
http://dx.doi.org/10.1038/ki.2013.68