Mutations in Arg143 and Lys192 of the Human Mast Cell Chymase Markedly Affect the Activity of Five Potent Human Chymase Inhibitors

Chymotrypsin-like serine proteases are found in high abundance in mast cell granules. By site-directed mutatgenesis, we have previously shown that basic amino acids in positions 143 and 192 (Arg and Lys respectively) of the human mast cell chymase are responsible for an acidic amino acid residue pre...

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Detalles Bibliográficos
Autores principales: Ahooghalandari, Parvin, Hanke, Nina, Thorpe, Michael, Witte, Andreas, Messinger, Josef, Hellman, Lars
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3686865/
https://www.ncbi.nlm.nih.gov/pubmed/23840386
http://dx.doi.org/10.1371/journal.pone.0065988

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3686865/
https://www.ncbi.nlm.nih.gov/pubmed/23840386
http://dx.doi.org/10.1371/journal.pone.0065988

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