Metabotropic glutamate receptor 5 positive allosteric modulators are neuroprotective in a mouse model of Huntington's disease

BACKGROUND AND PURPOSE: Huntington's disease (HD) is an autosomal dominant neurodegenerative disorder caused by a polyglutamine expansion in the huntingtin protein. We have previously demonstrated that the cell signalling of the metabotropic glutamate receptor 5 (mGluR5) is altered in a mouse m...

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Detalles Bibliográficos
Autores principales: Doria, JG, Silva, FR, Souza, JM, Vieira, LB, Carvalho, TG, Reis, HJ, Pereira, GS, Dobransky, T, Ribeiro, FM
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 2013
Materias:
Research Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3687670/
https://www.ncbi.nlm.nih.gov/pubmed/23489026
http://dx.doi.org/10.1111/bph.12164

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3687670/
https://www.ncbi.nlm.nih.gov/pubmed/23489026
http://dx.doi.org/10.1111/bph.12164

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