BAK multimerization for apoptosis, but not bid binding, is inhibited by negatively charged residue in the BAK hydrophobic groove

BACKGROUND: BCL-2 family proteins BAK and BAX orchestrate outer mitochondrial membrane permeabilization (MOMP) during apoptosis by forming pores in the membrane to release apoptogenic factors that commits a cell to death. BAK and BAX therefore function as a ‘point of no return’ in the apoptotic casc...

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Detalles Bibliográficos
Autores principales: Azad, Abul, Storey, Alan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2013
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3688461/
https://www.ncbi.nlm.nih.gov/pubmed/23782464
http://dx.doi.org/10.1186/1476-4598-12-65

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3688461/
https://www.ncbi.nlm.nih.gov/pubmed/23782464
http://dx.doi.org/10.1186/1476-4598-12-65

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