The Ability of Flux Balance Analysis to Predict Evolution of Central Metabolism Scales with the Initial Distance to the Optimum

The most powerful genome-scale framework to model metabolism, flux balance analysis (FBA), is an evolutionary optimality model. It hypothesizes selection upon a proposed optimality criterion in order to predict the set of internal fluxes that would maximize fitness. Here we present a direct test of...

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Detalles Bibliográficos
Autores principales: Harcombe, William R., Delaney, Nigel F., Leiby, Nicholas, Klitgord, Niels, Marx, Christopher J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3688462/
https://www.ncbi.nlm.nih.gov/pubmed/23818838
http://dx.doi.org/10.1371/journal.pcbi.1003091

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3688462/
https://www.ncbi.nlm.nih.gov/pubmed/23818838
http://dx.doi.org/10.1371/journal.pcbi.1003091

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