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Crystal Structure, SAXS and Kinetic Mechanism of Hyperthermophilic ADP-Dependent Glucokinase from Thermococcus litoralis Reveal a Conserved Mechanism for Catalysis

ADP-dependent glucokinases represent a unique family of kinases that belong to the ribokinase superfamily, being present mainly in hyperthermophilic archaea. For these enzymes there is no agreement about the magnitude of the structural transitions associated with ligand binding and whether they are...

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Detalles Bibliográficos
Autores principales: Rivas-Pardo, Jaime Andrés, Herrera-Morande, Alejandra, Castro-Fernandez, Victor, Fernandez, Francisco J., Vega, M. Cristina, Guixé, Victoria
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3688580/
https://www.ncbi.nlm.nih.gov/pubmed/23818958
http://dx.doi.org/10.1371/journal.pone.0066687