Cobalt-Alloy Implant Debris Induce HIF-1α Hypoxia Associated Responses: A Mechanism for Metal-Specific Orthopedic Implant Failure

The historical success of orthopedic implants has been recently tempered by unexpected pathologies and early failures of some types of Cobalt-Chromium-Molybdenum alloy containing artificial hip implants. Hypoxia-associated responses to Cobalt-alloy metal debris were suspected as mediating this untow...

Descripción completa

Detalles Bibliográficos
Autores principales: Samelko, Lauryn, Caicedo, Marco S., Lim, Seung-Jae, Della-Valle, Craig, Jacobs, Joshua, Hallab, Nadim J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3688623/
https://www.ncbi.nlm.nih.gov/pubmed/23840602
http://dx.doi.org/10.1371/journal.pone.0067127

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3688623/
https://www.ncbi.nlm.nih.gov/pubmed/23840602
http://dx.doi.org/10.1371/journal.pone.0067127

Ejemplares similares