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Cobalt-Alloy Implant Debris Induce HIF-1α Hypoxia Associated Responses: A Mechanism for Metal-Specific Orthopedic Implant Failure

The historical success of orthopedic implants has been recently tempered by unexpected pathologies and early failures of some types of Cobalt-Chromium-Molybdenum alloy containing artificial hip implants. Hypoxia-associated responses to Cobalt-alloy metal debris were suspected as mediating this untow...

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Detalles Bibliográficos
Autores principales:	Samelko, Lauryn, Caicedo, Marco S., Lim, Seung-Jae, Della-Valle, Craig, Jacobs, Joshua, Hallab, Nadim J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2013
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3688623/ https://www.ncbi.nlm.nih.gov/pubmed/23840602 http://dx.doi.org/10.1371/journal.pone.0067127

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