GATA-3 controls T cell maintenance and proliferation downstream of TCR and cytokine signals

GATA-3 is a master regulator for T(H)2 differentiation. It is however poorly understood if GATA-3 controls mature T cell function beyond T(H)2 determination. We show that TCR signals and cytokine stimulation promoted GATA-3 expression in CD8 T cells, which controlled cell proliferation. While GATA-3...

Descripción completa

Detalles Bibliográficos
Autores principales: Wang, Yunqi, Misumi, Ichiro, Gu, Ai-Di, Curtis, T. Anthony, Su, Lishan, Whitmire, Jason K., Wan, Yisong Y.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3688666/
https://www.ncbi.nlm.nih.gov/pubmed/23708251
http://dx.doi.org/10.1038/ni.2623

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3688666/
https://www.ncbi.nlm.nih.gov/pubmed/23708251
http://dx.doi.org/10.1038/ni.2623

Ejemplares similares