Efficient Deamination of 5-Methylcytidine and 5-Substituted Cytidine Residues in DNA by Human APOBEC3A Cytidine Deaminase

Deamination of 5-methylcytidine (5MeC) in DNA results in a G:T mismatch unlike cytidine (C) deamination which gives rise to a G:U pair. Deamination of C was generally considered to arise spontaneously. It is now clear that human APOBEC3A (A3A), a polynucleotide cytidine deaminase (PCD) with specific...

Descripción completa

Detalles Bibliográficos
Autores principales: Suspène, Rodolphe, Aynaud, Marie-Ming, Vartanian, Jean-Pierre, Wain-Hobson, Simon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3688686/
https://www.ncbi.nlm.nih.gov/pubmed/23840298
http://dx.doi.org/10.1371/journal.pone.0063461

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3688686/
https://www.ncbi.nlm.nih.gov/pubmed/23840298
http://dx.doi.org/10.1371/journal.pone.0063461

Ejemplares similares