Designed Azolopyridinium Salts Block Protective Antigen Pores In Vitro and Protect Cells from Anthrax Toxin

BACKGROUND: Several intracellular acting bacterial protein toxins of the AB-type, which are known to enter cells by endocytosis, are shown to produce channels. This holds true for protective antigen (PA), the binding component of the tripartite anthrax-toxin of Bacillus anthracis. Evidence has been...

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Detalles Bibliográficos
Autores principales: Beitzinger, Christoph, Bronnhuber, Anika, Duscha, Kerstin, Riedl, Zsuzsanna, Huber-Lang, Markus, Benz, Roland, Hajós, György, Barth, Holger
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3688708/
https://www.ncbi.nlm.nih.gov/pubmed/23840407
http://dx.doi.org/10.1371/journal.pone.0066099

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3688708/
https://www.ncbi.nlm.nih.gov/pubmed/23840407
http://dx.doi.org/10.1371/journal.pone.0066099

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