Cargando…

Designed Azolopyridinium Salts Block Protective Antigen Pores In Vitro and Protect Cells from Anthrax Toxin

BACKGROUND: Several intracellular acting bacterial protein toxins of the AB-type, which are known to enter cells by endocytosis, are shown to produce channels. This holds true for protective antigen (PA), the binding component of the tripartite anthrax-toxin of Bacillus anthracis. Evidence has been...

Descripción completa

Detalles Bibliográficos
Autores principales:	Beitzinger, Christoph, Bronnhuber, Anika, Duscha, Kerstin, Riedl, Zsuzsanna, Huber-Lang, Markus, Benz, Roland, Hajós, György, Barth, Holger
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2013
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3688708/ https://www.ncbi.nlm.nih.gov/pubmed/23840407 http://dx.doi.org/10.1371/journal.pone.0066099

Ejemplares similares

Cross-Reactivity of Anthrax and C2 Toxin: Protective Antigen Promotes the Uptake of Botulinum C2I Toxin into Human Endothelial Cells
por: Kronhardt, Angelika, et al.
Publicado: (2011)

Roles of Anthrax Toxin Receptor 2 in Anthrax Toxin Membrane Insertion and Pore Formation
por: Sun, Jianjun, et al.
Publicado: (2016)

Chloroquine Analog Interaction with C2- and Iota-Toxin in Vitro and in Living Cells
por: Kronhardt, Angelika, et al.
Publicado: (2016)

Polylysine-Mediated Translocation of the Diphtheria Toxin Catalytic Domain through the Anthrax Protective Antigen Pore
por: Sharma, Onkar, et al.
Publicado: (2014)

Role of N-Terminal His(6)-Tags in Binding and Efficient Translocation of Polypeptides into Cells Using Anthrax Protective Antigen (PA)
por: Beitzinger, Christoph, et al.
Publicado: (2012)

Disulfide Bonds in the Ectodomain of Anthrax Toxin Receptor 2 Are Required for the Receptor-Bound Protective-Antigen Pore to Function
por: Sun, Jianjun, et al.
Publicado: (2010)

Asymmetric Cryo-EM Structure of Anthrax Toxin Protective Antigen Pore with Lethal Factor N-Terminal Domain
por: Machen, Alexandra J., et al.
Publicado: (2017)

DARPins bind their cytosolic targets after having been translocated through the protective antigen pore of anthrax toxin
por: Becker, Lukas, et al.
Publicado: (2023)

The Disulfide Bond Cys255-Cys279 in the Immunoglobulin-Like Domain of Anthrax Toxin Receptor 2 Is Required for Membrane Insertion of Anthrax Protective Antigen Pore
por: Jacquez, Pedro, et al.
Publicado: (2015)

Atomic structure of anthrax PA pore elucidates toxin translocation
por: Jiang, Jiansen, et al.
Publicado: (2015)

A Protective Antigen Mutation Increases the pH Threshold of Anthrax Toxin Receptor 2-Mediated Pore Formation
por: Dennis, Melissa K., et al.
Publicado: (2014)

Anthrax toxin component, Protective Antigen, protects insects from bacterial infections
por: Alameh, Saleem, et al.
Publicado: (2020)

A Receptor-based Switch that Regulates Anthrax Toxin Pore Formation
por: Pilpa, Rosemarie M., et al.
Publicado: (2011)

Anthrax Toxin Receptor 2 Determinants that Dictate the pH Threshold of Toxin Pore Formation
por: Scobie, Heather M., et al.
Publicado: (2007)

Electrostatic Ratchet in the Protective Antigen Channel Promotes Anthrax Toxin Translocation
por: Wynia-Smith, Sarah L., et al.
Publicado: (2012)

GroEL as a molecular scaffold for structural analysis of the anthrax toxin pore
por: Katayama, Hiroo, et al.
Publicado: (2008)

Functions of Phenylalanine Residues within the β-Barrel Stem of the Anthrax Toxin Pore
por: Wang, Jie, et al.
Publicado: (2009)

Characterization and Pharmacological Inhibition of the Pore-Forming Clostridioides difficile CDTb Toxin
por: Ernst, Katharina, et al.
Publicado: (2021)

Tailored Cyclodextrin Pore Blocker Protects Mammalian Cells from Clostridium difficile Binary Toxin CDT
por: Roeder, Maurice, et al.
Publicado: (2014)

Delivery of Antibody Mimics into Mammalian Cells via Anthrax Toxin Protective Antigen
por: Liao, Xiaoli, et al.
Publicado: (2014)

Reengineering anthrax toxin protective antigen for improved receptor-specific protein delivery
por: Becker, Lukas, et al.
Publicado: (2020)

Anthrax vaccine design: strategies to achieve comprehensive protection against spore, bacillus, and toxin
por: Wang, Julia Y, et al.
Publicado: (2005)

Oxysterols Protect Epithelial Cells Against Pore-Forming Toxins
por: Ormsby, Thomas J. R., et al.
Publicado: (2022)

Immunization of Mice with Anthrax Protective Antigen Limits Cardiotoxicity but Not Hepatotoxicity Following Lethal Toxin Challenge
por: Devera, T. Scott, et al.
Publicado: (2015)

Anti-tumor activity of anthrax toxin variants that form a functional translocation pore by intermolecular complementation
por: Liu, Shihui, et al.
Publicado: (2017)

Anthrax toxin takes charge
por: Dove, Alan W.
Publicado: (2003)

Anthrax toxin rafts into cells
por: Kurzchalia, Teymuras
Publicado: (2003)

The Ins and Outs of Anthrax Toxin
por: Friebe, Sarah, et al.
Publicado: (2016)

LRP5 and LRP6 Are Not Required for Protective Antigen–Mediated Internalization or Lethality of Anthrax Lethal Toxin
por: Young, John J, et al.
Publicado: (2007)

In situ gastrointestinal protection against anthrax edema toxin by single-chain antibody fragment producing lactobacilli
por: Andersen, Kasper Krogh, et al.
Publicado: (2011)

Protective effect of anthrax toxin receptor 2 polymorphism rs4333130 against the risk of ankylosing spondylitis
por: Xu, Haitao, et al.
Publicado: (2020)

Atomic structures of anthrax toxin protective antigen channels bound to partially unfolded lethal and edema factors
por: Hardenbrook, Nathan J., et al.
Publicado: (2020)

Mechanisms protecting host cells against bacterial pore-forming toxins
por: Brito, Cláudia, et al.
Publicado: (2018)

Cryo-EM structure of the fully-loaded asymmetric anthrax lethal toxin in its heptameric pre-pore state
por: Antoni, Claudia, et al.
Publicado: (2020)

Cytoskeleton as an Emerging Target of Anthrax Toxins
por: Trescos, Yannick, et al.
Publicado: (2012)

Changing the Receptor Specificity of Anthrax Toxin
por: Mechaly, Adva, et al.
Publicado: (2012)

Anthrax Toxin-Expressing Bacillus cereus Isolated from an Anthrax-Like Eschar
por: Marston, Chung K., et al.
Publicado: (2016)

CRISPA: A Non-viral, Transient Cas9 Delivery System Based on Reengineered Anthrax Toxin
por: Hirschenberger, Maximilian, et al.
Publicado: (2021)

Divalent Metal Ion Coordination by Residue T118 of Anthrax Toxin Receptor 2 Is Not Essential for Protective Antigen Binding
por: Scobie, Heather M., et al.
Publicado: (2006)

Anthrax Toxin Receptor Drives Protective Antigen Oligomerization and Stabilizes the Heptameric and Octameric Oligomer by a Similar Mechanism
por: Kintzer, Alexander F., et al.
Publicado: (2010)

Cannot write session to /tmp/vufind_sessions/sess_qa6gs5ll6nn68qt37k9pjcbkhq