Circumventing Embryonic Lethality with Lcmt1 Deficiency: Generation of Hypomorphic Lcmt1 Mice with Reduced Protein Phosphatase 2A Methyltransferase Expression and Defects in Insulin Signaling

Protein phosphatase 2A (PP2A), the major serine/threonine phosphatase in eukaryotic cells, is a heterotrimeric protein composed of structural, catalytic, and targeting subunits. PP2A assembly is governed by a variety of mechanisms, one of which is carboxyl-terminal methylation of the catalytic subun...

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Detalles Bibliográficos
Autores principales: MacKay, Kennen B., Tu, Yiping, Young, Stephen G., Clarke, Steven G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3688711/
https://www.ncbi.nlm.nih.gov/pubmed/23840384
http://dx.doi.org/10.1371/journal.pone.0065967

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3688711/
https://www.ncbi.nlm.nih.gov/pubmed/23840384
http://dx.doi.org/10.1371/journal.pone.0065967

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