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Kinetic Proofreading at Single Molecular Level: Aminoacylation of tRNA(Ile) and the Role of Water as an Editor

Proofreading/editing in protein synthesis is essential for accurate translation of information from the genetic code. In this article we present a theoretical investigation of efficiency of a kinetic proofreading mechanism that employs hydrolysis of the wrong substrate as the discriminatory step in...

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Detalles Bibliográficos
Autores principales: Santra, Mantu, Bagchi, Biman
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3688713/
https://www.ncbi.nlm.nih.gov/pubmed/23840412
http://dx.doi.org/10.1371/journal.pone.0066112