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Epitope Mapping for Monoclonal Antibody Reveals the Activation Mechanism for αVβ3 Integrin
Epitopes for a panel of anti-αVβ3 monoclonal antibodies (mAbs) were investigated to explore the activation mechanism of αVβ3 integrin. Experiments utilizing αV/αIIb domain-swapping chimeras revealed that among the nine mAbs tested, five recognized the ligand-binding β-propeller domain and four recog...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2013
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3688720/ https://www.ncbi.nlm.nih.gov/pubmed/23840404 http://dx.doi.org/10.1371/journal.pone.0066096 |