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Epitope Mapping for Monoclonal Antibody Reveals the Activation Mechanism for αVβ3 Integrin

Epitopes for a panel of anti-αVβ3 monoclonal antibodies (mAbs) were investigated to explore the activation mechanism of αVβ3 integrin. Experiments utilizing αV/αIIb domain-swapping chimeras revealed that among the nine mAbs tested, five recognized the ligand-binding β-propeller domain and four recog...

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Detalles Bibliográficos
Autores principales:	Kamata, Tetsuji, Handa, Makoto, Takakuwa, Sonomi, Sato, Yukiko, Kawai, Yohko, Ikeda, Yasuo, Aiso, Sadakazu
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2013
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3688720/ https://www.ncbi.nlm.nih.gov/pubmed/23840404 http://dx.doi.org/10.1371/journal.pone.0066096

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