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The Antioxidant N-Acetylcysteine Prevents HIF-1 Stabilization under Hypoxia In Vitro but Does Not Affect Tumorigenesis in Multiple Breast Cancer Models In Vivo

Intratumoral hypoxia is a poor prognostic factor associated with reduced disease-free survival in many cancer types, including breast cancer. Hypoxia encourages tumor cell proliferation, stimulates angiogenesis and lymphangiogenesis, and promotes epithelial-mesenchymal transition and metastasis. Tum...

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Detalles Bibliográficos
Autores principales: Sceneay, Jaclyn, Liu, Mira C. P., Chen, Anna, Wong, Christina S. F., Bowtell, David D. L., Möller, Andreas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3688768/
https://www.ncbi.nlm.nih.gov/pubmed/23840457
http://dx.doi.org/10.1371/journal.pone.0066388