Expression of Epidermal Growth Factor Receptor Detected by Cetuximab Indicates Its Efficacy to Inhibit In Vitro and In Vivo Proliferation of Colorectal Cancer Cells

Cetuximab is a chimeric mouse–human monoclonal antibody that targets the human epidermal growth factor receptor (EGFR). However, EGFR expression determined by immunohistochemistry does not predict clinical outcomes of colorectal cancer (CRC) patients treated with cetuximab. Therefore, we evaluated t...

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Detalles Bibliográficos
Autores principales: Shigeta, Kohei, Hayashida, Tetsu, Hoshino, Yoshinori, Okabayashi, Koji, Endo, Takashi, Ishii, Yoshiyuki, Hasegawa, Hirotoshi, Kitagawa, Yuko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3688890/
https://www.ncbi.nlm.nih.gov/pubmed/23824671
http://dx.doi.org/10.1371/journal.pone.0066302

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3688890/
https://www.ncbi.nlm.nih.gov/pubmed/23824671
http://dx.doi.org/10.1371/journal.pone.0066302

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