Distinctive G Protein-Dependent Signaling by Protease-Activated Receptor 2 (PAR2) in Smooth Muscle: Feedback Inhibition of RhoA by cAMP-Independent PKA

We examined expression of protease-activated receptors 2 (PAR2) and characterized their signaling pathways in rabbit gastric muscle cells. The PAR2 activating peptide SLIGRL (PAR2-AP) stimulated G(q), G(13), G(i1), PI hydrolysis, and Rho kinase activity, and inhibited cAMP formation. Stimulation of...

Descripción completa

Detalles Bibliográficos
Autores principales: Sriwai, Wimolpak, Mahavadi, Sunila, Al-Shboul, Othman, Grider, John R., Murthy, Karnam S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3688948/
https://www.ncbi.nlm.nih.gov/pubmed/23825105
http://dx.doi.org/10.1371/journal.pone.0066743

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3688948/
https://www.ncbi.nlm.nih.gov/pubmed/23825105
http://dx.doi.org/10.1371/journal.pone.0066743

Ejemplares similares