The metabolism of primaquine to its active metabolite is dependent on CYP 2D6

BACKGROUND: The efficacy of the 8-aminoquinoline (8AQ) drug primaquine (PQ) has been historically linked to CYP-mediated metabolism. Although to date no clear evidence exists in the literature that unambiguously assigns the metabolic pathway or specific metabolites necessary for activity, recent lit...

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Detalles Bibliográficos
Autores principales: Pybus, Brandon S, Marcsisin, Sean R, Jin, Xiannu, Deye, Gregory, Sousa, Jason C, Li, Qigui, Caridha, Diana, Zeng, Qiang, Reichard, Gregory A, Ockenhouse, Christian, Bennett, Jason, Walker, Larry A, Ohrt, Colin, Melendez, Victor
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2013
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3689079/
https://www.ncbi.nlm.nih.gov/pubmed/23782898
http://dx.doi.org/10.1186/1475-2875-12-212

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3689079/
https://www.ncbi.nlm.nih.gov/pubmed/23782898
http://dx.doi.org/10.1186/1475-2875-12-212

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