Transcription forms and remodels supercoiling domains unfolding large-scale chromatin structures

DNA supercoiling is an inherent consequence of twisting DNA and is critical for regulating gene expression and DNA replication. However, DNA supercoiling at a genomic scale in human cells is uncharacterized. To map supercoiling we used biotinylated-trimethylpsoralen as a DNA structure probe to show...

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Detalles Bibliográficos
Autores principales: Naughton, Catherine, Avlonitis, Nicolaos, Corless, Samuel, Prendergast, James G., Mati, Ioulia K., Eijk, Paul P., Cockroft, Scott L., Bradley, Mark, Ylstra, Bauke, Gilbert, Nick
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3689368/
https://www.ncbi.nlm.nih.gov/pubmed/23416946
http://dx.doi.org/10.1038/nsmb.2509

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3689368/
https://www.ncbi.nlm.nih.gov/pubmed/23416946
http://dx.doi.org/10.1038/nsmb.2509

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