Expression Enhancement in Trastuzumab Therapeutic Monoclonal Antibody Production using Genomic Amplification with Methotrexate

BACKGROUND: Trastuzumab (Herceptin) is a humanized monoclonal antibody (mAb) which is used for specific treatment of metastatic breast cancer in patients with overexpression of HER2/neu receptor. In this study, we have attempted to develop a biosimilar version of trastuzumab mAb. METHODS: According...

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Detalles Bibliográficos
Autores principales: Akbarzadeh-Sharbaf, Soudabeh, Yakhchali, Bagher, Minuchehr, Zarrin, Shokrgozar, Mohammad Ali, Zeinali, Sirous
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Avicenna Research Institute 2013
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3689561/
https://www.ncbi.nlm.nih.gov/pubmed/23799177

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3689561/
https://www.ncbi.nlm.nih.gov/pubmed/23799177

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