Cargando…

Expression Enhancement in Trastuzumab Therapeutic Monoclonal Antibody Production using Genomic Amplification with Methotrexate

BACKGROUND: Trastuzumab (Herceptin) is a humanized monoclonal antibody (mAb) which is used for specific treatment of metastatic breast cancer in patients with overexpression of HER2/neu receptor. In this study, we have attempted to develop a biosimilar version of trastuzumab mAb. METHODS: According...

Descripción completa

Detalles Bibliográficos
Autores principales:	Akbarzadeh-Sharbaf, Soudabeh, Yakhchali, Bagher, Minuchehr, Zarrin, Shokrgozar, Mohammad Ali, Zeinali, Sirous
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Avicenna Research Institute 2013
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3689561/ https://www.ncbi.nlm.nih.gov/pubmed/23799177

Ejemplares similares

In silico design, construction and cloning of Trastuzumab humanized monoclonal antibody: A possible biosimilar for Herceptin
por: Akbarzadeh-Sharbaf, Soudabeh, et al.
Publicado: (2012)

The distribution of the therapeutic monoclonal antibodies cetuximab and trastuzumab within solid tumors
por: Lee, Carol M, et al.
Publicado: (2010)

Hepatitis B Virus Genome Asymmetry in Hepatocellular Carcinoma
por: Shokrgozar, Zahra, et al.
Publicado: (2012)

Identification of Natural Products as SENP2 Inhibitors for Targeted Therapy in Heart Failure
por: Taghvaei, Somayye, et al.
Publicado: (2022)

The arrival of biosimilar monoclonal antibodies in oncology: clinical studies for trastuzumab biosimilars
por: Barbier, Liese, et al.
Publicado: (2019)

MiRNAs Which Target CD3 Subunits Could Be Potential Biomarkers for Cancers
por: Asghari Alashti, Fariborz, et al.
Publicado: (2013)

Binding Affinity of Trastuzumab and Pertuzumab Monoclonal Antibodies to Extracellular HER2 Domain †
por: Cruz, Victor L., et al.
Publicado: (2023)

Evidence of Omics, Immune Infiltration, and Pharmacogenomic for SENP1 in the Pan-Cancer Cohort
por: Taghvaei, Somayye, et al.
Publicado: (2021)

Gastric cancer biomarkers; A systems biology approach
por: Saberi Anvar, Mohammad, et al.
Publicado: (2018)

Analysis of microRNA and Gene Expression Profiles in Alzheimer’s Disease: A Meta-Analysis Approach
por: Moradifard, Shirin, et al.
Publicado: (2018)

A rapid method for relative quantification of N-glycans from a therapeutic monoclonal antibody during trastuzumab biosimilar development
por: Segu, Zaneer, et al.
Publicado: (2020)

Exploring the cross talk between ER stress and inflammation in age-related macular degeneration
por: Kheitan, Samira, et al.
Publicado: (2017)

TGM2, HMGA2, FXYD3, and LGALS4 genes as biomarkers in acquired oxaliplatin resistance of human colorectal cancer: A systems biology approach
por: Cheraghi-shavi, Tayebeh, et al.
Publicado: (2023)

An Ontology-Based GIS for Genomic Data Management of Rumen Microbes
por: Jelokhani-Niaraki, Saber, et al.
Publicado: (2015)

A bispecific monoclonal antibody against methotrexate and a human tumour associated antigen augments cytotoxicity of methotrexate-carrier conjugate.
por: Pimm, M. V., et al.
Publicado: (1990)

Autophagy Facilitates the Development of Breast Cancer Resistance to the Anti-HER2 Monoclonal Antibody Trastuzumab
por: Vazquez-Martin, Alejandro, et al.
Publicado: (2009)

Therapeutic Monoclonal Antibodies and Antibody Products: Current Practices and Development in Multiple Myeloma
por: Bonello, Francesca, et al.
Publicado: (2019)

Monoclonal antibody targeting of methotrexate (MTX) against MTX-resistant tumour cell lines.
por: Affleck, K., et al.
Publicado: (1992)

Therapeutic monoclonal antibody for sporotrichosis
por: Almeida, Sandro R.
Publicado: (2012)

Therapeutic Applications of Monoclonal Antibodies
por: Berger, Mitchell, et al.
Publicado: (2002)

Monoclonal Antibodies as Neurological Therapeutics
por: Gklinos, Panagiotis, et al.
Publicado: (2021)

Chameleon sequences in neurodegenerative diseases
por: Bahramali, Golnaz, et al.
Publicado: (2016)

Study of DACH1 Expression and its Epigenetic Regulators as Possible Breast Cancer-Related Biomarkers
por: Nasirpour, Mohammad Hossein, et al.
Publicado: (2023)

Recent advances in targeted therapy of colorectal cancer: impacts of monoclonal antibodies nanoconjugates
por: Akbarzadeh Khiavi, Mostafa, et al.
Publicado: (2019)

A comparative study on the physicochemical and biological stability of IgG(1) and monoclonal antibodies during spray drying process
por: Ramezani, Vahid, et al.
Publicado: (2014)

Effect of Microencapsulation Shear Stress on the Structural Integrity and Biological Activity of a Model Monoclonal Antibody, Trastuzumab
por: Pabari, Ritesh M., et al.
Publicado: (2011)

Conjugate of PAMAM Dendrimer, Doxorubicin and Monoclonal Antibody—Trastuzumab: The New Approach of a Well-Known Strategy
por: Marcinkowska, Monika, et al.
Publicado: (2018)

Therapeutic Monoclonal Antibodies and Emergence of Their Biosimilars
por: Jeddi-Tehrani, Mahmood
Publicado: (2018)

The pharmacology and therapeutic applications of monoclonal antibodies
por: Castelli, María Sofía, et al.
Publicado: (2019)

Production of Monoclonal Antibody against Human Nestin
por: Hadavi, Reza, et al.
Publicado: (2010)

Computational study of SENP1 in cancer by novel natural compounds and ZINC database screening
por: Taghvaei, Somayye, et al.
Publicado: (2023)

Anti-IGF-1R monoclonal antibody inhibits the carcinogenicity activity of acquired trastuzumab-resistant SKOV3
por: Wang, Wei, et al.
Publicado: (2014)

Betanin purification from red beetroots and evaluation of its anti-oxidant and anti-inflammatory activity on LPS-activated microglial cells
por: Ahmadi, Hosein, et al.
Publicado: (2020)

Microbials for the production of monoclonal antibodies and antibody fragments
por: Spadiut, Oliver, et al.
Publicado: (2014)

Activation of methotrexate-phenylalanine by monoclonal antibody--carboxypeptidase A conjugate for the specific treatment of ovarian cancer in vitro.
por: Perron, M. J., et al.
Publicado: (1996)

Quality Control and Stability Studies with the Monoclonal Antibody, Trastuzumab: Application of 1D- vs. 2D-Gel Electrophoresis
por: Nebija, Dashnor, et al.
Publicado: (2014)

Applicability of Traditional In Vitro Toxicity Tests for Assessing Adverse Effects of Monoclonal Antibodies: A Case Study of Rituximab and Trastuzumab
por: Kizhedath, Arathi, et al.
Publicado: (2018)

Developing therapeutic monoclonal antibodies at pandemic pace
por: Kelley, Brian
Publicado: (2020)

Methotrexate; a trustworthy answer to an inflammatory response in osteoarthritis
por: Mehrpoor, Golbarg, et al.
Publicado: (2022)

Trastuzumab in combination with metronomic cyclophosphamide and methotrexate in patients with HER-2 positive metastatic breast cancer
por: Orlando, Laura, et al.
Publicado: (2006)

Cannot write session to /tmp/vufind_sessions/sess_umf5ackfcp25b3udvslee0glo5