Cell cycle-dependent activity of the novel dual PI3K-MTORC1/2 inhibitor NVP-BGT226 in acute leukemia

BACKGROUND: Dysregulation of the PI3Kinase/AKT pathway is involved in the pathogenesis of many human malignancies. In acute leukemia, the AKT pathway is frequently activated, however mutations in the PI3K/AKT pathway are uncommon. In some cases, constitutive AKT activation can be linked to gain-of-f...

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Detalles Bibliográficos
Autores principales: Kampa-Schittenhelm, Kerstin Maria, Heinrich, Michael Charles, Akmut, Figen, Rasp, Katharina Henriette, Illing, Barbara, Döhner, Hartmut, Döhner, Konstanze, Schittenhelm, Marcus Matthias
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2013
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3689638/
https://www.ncbi.nlm.nih.gov/pubmed/23705826
http://dx.doi.org/10.1186/1476-4598-12-46

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3689638/
https://www.ncbi.nlm.nih.gov/pubmed/23705826
http://dx.doi.org/10.1186/1476-4598-12-46

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