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Drug Promiscuity in PDB: Protein Binding Site Similarity Is Key
Drug repositioning applies established drugs to new disease indications with increasing success. A pre-requisite for drug repurposing is drug promiscuity (polypharmacology) – a drug’s ability to bind to several targets. There is a long standing debate on the reasons for drug promiscuity. Based on la...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Public Library of Science
2013
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3689763/ https://www.ncbi.nlm.nih.gov/pubmed/23805191 http://dx.doi.org/10.1371/journal.pone.0065894 |