Cooperative Assembly of a Protein-DNA Filament for Nonhomologous End Joining

Nonhomologous end joining repairs DNA double-strand breaks created by ionizing radiation and V(D)J recombination. Ku, XRCC4/Ligase IV (XL), and XLF have a remarkable mismatched end (MEnd) ligase activity, particularly for ends with mismatched 3′ overhangs, but the mechanism has remained obscure. Her...

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Detalles Bibliográficos
Autores principales: Tsai, Chun J., Chu, Gilbert
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2013
Materias:
DNA and Chromosomes
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3689955/
https://www.ncbi.nlm.nih.gov/pubmed/23620595
http://dx.doi.org/10.1074/jbc.M113.464115

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3689955/
https://www.ncbi.nlm.nih.gov/pubmed/23620595
http://dx.doi.org/10.1074/jbc.M113.464115

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