BH3 Response Profiles From Neuroblastoma Mitochondria Predict Activity of Small Molecule Bcl-2 Family Antagonists

Bcl-2 family proteins regulate mitochondrial apoptosis downstream of diverse stressors. Cancer cells frequently deregulate Bcl-2 proteins leading to chemoresistance. We have optimized a platform for solid tumors in which Bcl-2 family resistance patterns are inferred. Functional mitochondria were iso...

Descripción completa

Detalles Bibliográficos
Autores principales: Goldsmith, Kelly C., Lestini, Brian J., Gross, Michelle, Ip, Laura, Bhumbla, Ashish, Zhang, Xuemei, Zhao, Huaqing, Liu, Xueyuan, Hogarty, Michael D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2009
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3690273/
https://www.ncbi.nlm.nih.gov/pubmed/19893570
http://dx.doi.org/10.1038/cdd.2009.171

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3690273/
https://www.ncbi.nlm.nih.gov/pubmed/19893570
http://dx.doi.org/10.1038/cdd.2009.171

Ejemplares similares