Cargando…

BH3 Response Profiles From Neuroblastoma Mitochondria Predict Activity of Small Molecule Bcl-2 Family Antagonists

Bcl-2 family proteins regulate mitochondrial apoptosis downstream of diverse stressors. Cancer cells frequently deregulate Bcl-2 proteins leading to chemoresistance. We have optimized a platform for solid tumors in which Bcl-2 family resistance patterns are inferred. Functional mitochondria were iso...

Descripción completa

Detalles Bibliográficos
Autores principales:	Goldsmith, Kelly C., Lestini, Brian J., Gross, Michelle, Ip, Laura, Bhumbla, Ashish, Zhang, Xuemei, Zhao, Huaqing, Liu, Xueyuan, Hogarty, Michael D.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2009
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3690273/ https://www.ncbi.nlm.nih.gov/pubmed/19893570 http://dx.doi.org/10.1038/cdd.2009.171

Ejemplares similares

BCL2-BH4 antagonist BDA-366 suppresses human myeloma growth
por: Deng, Jiusheng, et al.
Publicado: (2016)

Reduced ER–mitochondria connectivity promotes neuroblastoma multidrug resistance
por: Çoku, Jorida, et al.
Publicado: (2022)

BH4-mimetics and -antagonists: an emerging class of Bcl-2 protein modulators for cancer therapy
por: Nougarède, Adrien, et al.
Publicado: (2018)

The restricted binding repertoire of Bcl-B leaves Bim as the universal BH3-only prosurvival Bcl-2 protein antagonist
por: Rautureau, G J P, et al.
Publicado: (2012)

Novel BH4-BCL-2 Domain Antagonists Induce BCL-2-Mediated Apoptosis in Triple-Negative Breast Cancer
por: Kanakaveti, Vishnupriya, et al.
Publicado: (2022)

A direct comparison of selective BH3-mimetics reveals BCL-X(L), BCL-2 and MCL-1 as promising therapeutic targets in neuroblastoma
por: Bierbrauer, Annika, et al.
Publicado: (2020)

Select Bcl-2 antagonism restores chemotherapy sensitivity in high-risk neuroblastoma
por: Tanos, Rachel, et al.
Publicado: (2016)

BCL2DB: database of BCL-2 family members and BH3-only proteins
por: Rech de Laval, Valentine, et al.
Publicado: (2014)

Mutual Regulation of Bcl-2 Proteins Independent of the BH3 Domain as Shown by the BH3-Lacking Protein Bcl-x(AK)
por: Plötz, Michael, et al.
Publicado: (2012)

Optimization and validation of mitochondria-based functional assay as a useful tool to identify BH3-like molecules selectively targeting anti-apoptotic Bcl-2 proteins
por: Long, Jianting, et al.
Publicado: (2013)

Polyamine pathway inhibition as a novel therapeutic approach to treating neuroblastoma
por: Gamble, Laura D., et al.
Publicado: (2012)

Antagonizing Bcl-2′s BH4 domain in cancer
por: Vervloessem, Tamara, et al.
Publicado: (2015)

BDA-366, a putative Bcl-2 BH4 domain antagonist, induces apoptosis independently of Bcl-2 in a variety of cancer cell models
por: Vervloessem, Tamara, et al.
Publicado: (2020)

During negative selection, Nur77 family proteins translocate to mitochondria where they associate with Bcl-2 and expose its proapoptotic BH3 domain
por: Thompson, Jennifer, et al.
Publicado: (2008)

BH3-profiling identifies heterogeneous dependency on Bcl-2 family members in Multiple Myeloma and predicts sensitivity to BH3 mimetics
por: Touzeau, Cyrille, et al.
Publicado: (2015)

CYD0281, a Bcl-2 BH4 domain antagonist, inhibits tumor angiogenesis and breast cancer tumor growth
por: Lin, Yihua, et al.
Publicado: (2023)

BCL-2 family deregulation in colorectal cancer: potential for BH3 mimetics in therapy
por: Ramesh, Prashanthi, et al.
Publicado: (2020)

Small-molecule Bcl-2 antagonists as targeted therapy in oncology
por: Warr, M.R., et al.
Publicado: (2008)

Molecular Interactions of Prodiginines with the BH3 Domain of Anti-Apoptotic Bcl-2 Family Members
por: Hosseini, Ali, et al.
Publicado: (2013)

The BH3 only Bcl-2 family member BNIP3 regulates cellular proliferation
por: Singh, Amandeep, et al.
Publicado: (2018)

Multiple components of the spliceosome regulate Mcl1 activity in neuroblastoma
por: Laetsch, T W, et al.
Publicado: (2014)

Prognostic impact of the expression/phosphorylation of the BH3-only proteins of the BCL-2 family in glioblastoma multiforme
por: Cartron, P F, et al.
Publicado: (2012)

BH4 domain peptides derived from Bcl-2/Bcl-XL as novel tools against acute pancreatitis
por: Vervliet, Tim, et al.
Publicado: (2018)

A New Player in Neuroblastoma: YAP and Its Role in the Neuroblastoma Microenvironment
por: Shim, Jenny, et al.
Publicado: (2021)

Targeting BCL-2–expressing basal-like breast cancer with BH3-mimetics
por: Oakes, SR, et al.
Publicado: (2012)

Telomerase Reverse Transcriptase Contains a BH3-Like Motif and Interacts with BCL-2 Family Members
por: Jin, Young, et al.
Publicado: (2018)

A synthetic peptide targeting the BH4 domain of Bcl-2 induces apoptosis in multiple myeloma and follicular lymphoma cells alone or in combination with agents targeting the BH3-binding pocket of Bcl-2
por: Lavik, Andrew R., et al.
Publicado: (2015)

Mutations in PIK3CA are infrequent in neuroblastoma
por: Dam, Vincent, et al.
Publicado: (2006)

Ryanodine receptors are targeted by anti-apoptotic Bcl-X(L) involving its BH4 domain and Lys87 from its BH3 domain
por: Vervliet, Tim, et al.
Publicado: (2015)

Structural Investigation of Orf Virus Bcl-2 Homolog ORFV125 Interactions with BH3-Motifs from BH3-Only Proteins Puma and Hrk
por: Suraweera, Chathura D., et al.
Publicado: (2021)

Antagonizing Bcl-2 Family Members Sensitizes Neuroblastoma and Ewing’s Sarcoma to an Inhibitor of Glutamine Metabolism
por: Olsen, Rachelle R., et al.
Publicado: (2015)

Bim escapes displacement by BH3-mimetic anti-cancer drugs by double-bolt locking both Bcl-XL and Bcl-2
por: Liu, Qian, et al.
Publicado: (2019)

Bcl-2 regulates pyroptosis and necroptosis by targeting BH3-like domains in GSDMD and MLKL
por: Shi, Chong-Shan, et al.
Publicado: (2019)

Competition Between Phenothiazines and BH3 Peptide for the Binding Site of the Antiapoptotic BCL-2 Protein
por: do Carmo, Aline Lagoeiro, et al.
Publicado: (2020)

Bax activation by the BH3-only protein Puma promotes cell dependence on antiapoptotic Bcl-2 family members
por: Gallenne, Tristan, et al.
Publicado: (2009)

Selective regulation of IP(3)-receptor-mediated Ca(2+) signaling and apoptosis by the BH4 domain of Bcl-2 versus Bcl-Xl
por: Monaco, G, et al.
Publicado: (2012)

Specific interactions of BCL-2 family proteins mediate sensitivity to BH3-mimetics in diffuse large B-cell lymphoma
por: Smith, Victoria M., et al.
Publicado: (2020)

Mitochondrial permeabilization relies on BH3 ligands engaging multiple prosurvival Bcl-2 relatives, not Bak
por: Uren, Rachel T., et al.
Publicado: (2007)

Domain-specific insight into the recognition of BH3-death motifs by the pro-survival Bcl-2 protein
por: Mushtaq, Ameeq Ul, et al.
Publicado: (2022)

Increased MCL1 dependency leads to new applications of BH3-mimetics in drug-resistant neuroblastoma
por: Jacob, Maureen, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_glg99ht54npbe760m26du7cvoa