Cargando…

Weft, Warp, and Weave: The Intricate Tapestry of Calcium Channels Regulating T Lymphocyte Function

Calcium (Ca(2+)) is a universal second messenger important for T lymphocyte homeostasis, activation, proliferation, differentiation, and apoptosis. The events surrounding Ca(2+) mobilization in lymphocytes are tightly regulated and involve the coordination of diverse ion channels, membrane receptors...

Descripción completa

Detalles Bibliográficos
Autores principales: Omilusik, Kyla D., Nohara, Lilian L., Stanwood, Shawna, Jefferies, Wilfred A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3690356/
https://www.ncbi.nlm.nih.gov/pubmed/23805141
http://dx.doi.org/10.3389/fimmu.2013.00164
_version_ 1782274372762861568
author Omilusik, Kyla D.
Nohara, Lilian L.
Stanwood, Shawna
Jefferies, Wilfred A.
author_facet Omilusik, Kyla D.
Nohara, Lilian L.
Stanwood, Shawna
Jefferies, Wilfred A.
author_sort Omilusik, Kyla D.
collection PubMed
description Calcium (Ca(2+)) is a universal second messenger important for T lymphocyte homeostasis, activation, proliferation, differentiation, and apoptosis. The events surrounding Ca(2+) mobilization in lymphocytes are tightly regulated and involve the coordination of diverse ion channels, membrane receptors, and signaling molecules. A mechanism termed store-operated Ca(2+) entry (SOCE), causes depletion of endoplasmic reticulum (ER) Ca(2+) stores following T cell receptor (TCR) engagement and triggers a sustained influx of extracellular Ca(2+) through Ca(2+) release-activated Ca(2+) (CRAC) channels in the plasma membrane. The ER Ca(2+) sensing molecule, stromal interaction molecule 1 (STIM1), and a pore-forming plasma membrane protein, ORAI1, have been identified as important mediators of SOCE. Here, we review the role of several additional families of Ca(2+) channels expressed on the plasma membrane of T cells that likely contribute to Ca(2+) influx following TCR engagement, particularly highlighting an important role for voltage-dependent Ca(2+) channels (Ca(V)) in T lymphocyte biology.
format Online
Article
Text
id pubmed-3690356
institution National Center for Biotechnology Information
language English
publishDate 2013
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-36903562013-06-26 Weft, Warp, and Weave: The Intricate Tapestry of Calcium Channels Regulating T Lymphocyte Function Omilusik, Kyla D. Nohara, Lilian L. Stanwood, Shawna Jefferies, Wilfred A. Front Immunol Immunology Calcium (Ca(2+)) is a universal second messenger important for T lymphocyte homeostasis, activation, proliferation, differentiation, and apoptosis. The events surrounding Ca(2+) mobilization in lymphocytes are tightly regulated and involve the coordination of diverse ion channels, membrane receptors, and signaling molecules. A mechanism termed store-operated Ca(2+) entry (SOCE), causes depletion of endoplasmic reticulum (ER) Ca(2+) stores following T cell receptor (TCR) engagement and triggers a sustained influx of extracellular Ca(2+) through Ca(2+) release-activated Ca(2+) (CRAC) channels in the plasma membrane. The ER Ca(2+) sensing molecule, stromal interaction molecule 1 (STIM1), and a pore-forming plasma membrane protein, ORAI1, have been identified as important mediators of SOCE. Here, we review the role of several additional families of Ca(2+) channels expressed on the plasma membrane of T cells that likely contribute to Ca(2+) influx following TCR engagement, particularly highlighting an important role for voltage-dependent Ca(2+) channels (Ca(V)) in T lymphocyte biology. Frontiers Media S.A. 2013-06-24 /pmc/articles/PMC3690356/ /pubmed/23805141 http://dx.doi.org/10.3389/fimmu.2013.00164 Text en Copyright © 2013 Omilusik, Nohara, Stanwood and Jefferies. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in other forums, provided the original authors and source are credited and subject to any copyright notices concerning any third-party graphics etc.
spellingShingle Immunology
Omilusik, Kyla D.
Nohara, Lilian L.
Stanwood, Shawna
Jefferies, Wilfred A.
Weft, Warp, and Weave: The Intricate Tapestry of Calcium Channels Regulating T Lymphocyte Function
title Weft, Warp, and Weave: The Intricate Tapestry of Calcium Channels Regulating T Lymphocyte Function
title_full Weft, Warp, and Weave: The Intricate Tapestry of Calcium Channels Regulating T Lymphocyte Function
title_fullStr Weft, Warp, and Weave: The Intricate Tapestry of Calcium Channels Regulating T Lymphocyte Function
title_full_unstemmed Weft, Warp, and Weave: The Intricate Tapestry of Calcium Channels Regulating T Lymphocyte Function
title_short Weft, Warp, and Weave: The Intricate Tapestry of Calcium Channels Regulating T Lymphocyte Function
title_sort weft, warp, and weave: the intricate tapestry of calcium channels regulating t lymphocyte function
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3690356/
https://www.ncbi.nlm.nih.gov/pubmed/23805141
http://dx.doi.org/10.3389/fimmu.2013.00164
work_keys_str_mv AT omilusikkylad weftwarpandweavetheintricatetapestryofcalciumchannelsregulatingtlymphocytefunction
AT noharalilianl weftwarpandweavetheintricatetapestryofcalciumchannelsregulatingtlymphocytefunction
AT stanwoodshawna weftwarpandweavetheintricatetapestryofcalciumchannelsregulatingtlymphocytefunction
AT jefferieswilfreda weftwarpandweavetheintricatetapestryofcalciumchannelsregulatingtlymphocytefunction