Structure of Rhomboid Protease in Complex with β-Lactam Inhibitors Defines the S2′ Cavity

Rhomboids are evolutionarily conserved serine proteases that cleave transmembrane proteins within the membrane. The increasing number of known rhomboid functions in prokaryotes and eukaryotes makes them attractive drug targets. Here, we describe structures of the Escherichia coli rhomboid GlpG in co...

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Detalles Bibliográficos
Autores principales: Vinothkumar, Kutti R., Pierrat, Olivier A., Large, Jonathan M., Freeman, Matthew
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2013
Materias:
Short Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3690538/
https://www.ncbi.nlm.nih.gov/pubmed/23665170
http://dx.doi.org/10.1016/j.str.2013.03.013

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3690538/
https://www.ncbi.nlm.nih.gov/pubmed/23665170
http://dx.doi.org/10.1016/j.str.2013.03.013

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