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Structure of Rhomboid Protease in Complex with β-Lactam Inhibitors Defines the S2′ Cavity
Rhomboids are evolutionarily conserved serine proteases that cleave transmembrane proteins within the membrane. The increasing number of known rhomboid functions in prokaryotes and eukaryotes makes them attractive drug targets. Here, we describe structures of the Escherichia coli rhomboid GlpG in co...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Cell Press
2013
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3690538/ https://www.ncbi.nlm.nih.gov/pubmed/23665170 http://dx.doi.org/10.1016/j.str.2013.03.013 |