KlenTaq polymerase replicates unnatural base pairs by inducing a Watson-Crick geometry

Many candidate unnatural DNA base pairs have been developed, but surprisingly, some of the best replicated adopt intercalated structures in free DNA that are difficult to reconcile with known mechanisms of polymerase recognition. Here we present crystal structures of KlenTaq DNA polymerase at differ...

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Detalles Bibliográficos
Autores principales: Betz, Karin, Malyshev, Denis A., Lavergne, Thomas, Welte, Wolfram, Diederichs, Kay, Dwyer, Tammy J., Ordoukhanian, Phillip, Romesberg, Floyd E., Marx, Andreas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3690913/
https://www.ncbi.nlm.nih.gov/pubmed/22660438
http://dx.doi.org/10.1038/nchembio.966

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3690913/
https://www.ncbi.nlm.nih.gov/pubmed/22660438
http://dx.doi.org/10.1038/nchembio.966

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