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Active-State Models of Ternary GPCR Complexes: Determinants of Selective Receptor-G-Protein Coupling
Based on the recently described crystal structure of the β(2) adrenergic receptor - G(s)-protein complex, we report the first molecular-dynamics simulations of ternary GPCR complexes designed to identify the selectivity determinants for receptor-G-protein binding. Long-term molecular dynamics simula...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2013
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3691126/ https://www.ncbi.nlm.nih.gov/pubmed/23826246 http://dx.doi.org/10.1371/journal.pone.0067244 |