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Active-State Models of Ternary GPCR Complexes: Determinants of Selective Receptor-G-Protein Coupling

Based on the recently described crystal structure of the β(2) adrenergic receptor - G(s)-protein complex, we report the first molecular-dynamics simulations of ternary GPCR complexes designed to identify the selectivity determinants for receptor-G-protein binding. Long-term molecular dynamics simula...

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Detalles Bibliográficos
Autores principales:	Kling, Ralf C., Lanig, Harald, Clark, Timothy, Gmeiner, Peter
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2013
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3691126/ https://www.ncbi.nlm.nih.gov/pubmed/23826246 http://dx.doi.org/10.1371/journal.pone.0067244

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