An HIV-1 Envelope Glycoprotein Trimer with an Embedded IL-21 Domain Activates Human B Cells

Broadly neutralizing antibodies (bNAbs) that target the HIV-1 envelope glycoproteins (Env) can prevent virus acquisition, but several Env properties limit its ability to induce an antibody response that is of sufficient quantity and quality. The immunogenicity of Env can be increased by fusion to co...

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Detalles Bibliográficos
Autores principales: Isik, Gözde, Chung, Nancy P. Y., van Montfort, Thijs, Menis, Sergey, Matthews, Katie, Schief, William R., Moore, John P., Sanders, Rogier W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3691133/
https://www.ncbi.nlm.nih.gov/pubmed/23826263
http://dx.doi.org/10.1371/journal.pone.0067309

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3691133/
https://www.ncbi.nlm.nih.gov/pubmed/23826263
http://dx.doi.org/10.1371/journal.pone.0067309

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