Native Pyroglutamation of Huwentoxin-IV: A Post-Translational Modification that Increases the Trapping Ability to the Sodium Channel

Huwentoxin-IV (HWTX-IV), a tetrodotoxin-sensitive (TTX-s) sodium channel antagonist, is found in the venom of the Chinese spider Ornithoctonus huwena. A naturally modified HWTX-IV (mHWTX-IV), having a molecular mass 18 Da lower than HWTX-IV, has also been isolated from the venom of the same spider....

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Detalles Bibliográficos
Autores principales: Rong, Mingqiang, Duan, Zhigui, Chen, Juliang, Li, Jianglin, Xiao, Yuchen, Liang, Songping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3691182/
https://www.ncbi.nlm.nih.gov/pubmed/23826086
http://dx.doi.org/10.1371/journal.pone.0065984

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3691182/
https://www.ncbi.nlm.nih.gov/pubmed/23826086
http://dx.doi.org/10.1371/journal.pone.0065984

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