Cargando…

Inferring Epitopes of a Polymorphic Antigen Amidst Broadly Cross-Reactive Antibodies Using Protein Microarrays: A Study of OspC Proteins of Borrelia burgdorferi

Epitope mapping studies aim to identify the binding sites of antibody-antigen interactions to enhance the development of vaccines, diagnostics and immunotherapeutic compounds. However, mapping is a laborious process employing time- and resource-consuming ‘wet bench’ techniques or epitope prediction...

Descripción completa

Detalles Bibliográficos
Autores principales:	Baum, Elisabeth, Randall, Arlo Z., Zeller, Michael, Barbour, Alan G.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2013
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3691210/ https://www.ncbi.nlm.nih.gov/pubmed/23826301 http://dx.doi.org/10.1371/journal.pone.0067445

Ejemplares similares

Evolution and Distribution of the ospC Gene, a Transferable Serotype Determinant of Borrelia burgdorferi
por: Barbour, Alan G., et al.
Publicado: (2010)

An Inverted Repeat in the ospC Operator Is Required for Induction in Borrelia burgdorferi
por: Drecktrah, Dan, et al.
Publicado: (2013)

Investigation of ospC Expression Variation among Borrelia burgdorferi Strains
por: Xiang, Xuwu, et al.
Publicado: (2017)

Oral Immunization with OspC Does Not Prevent Tick-Borne Borrelia burgdorferi Infection
por: Melo, Rita, et al.
Publicado: (2016)

A Borrelia burgdorferi outer surface protein C (OspC) genotyping method using Luminex technology
por: Pearson, Patrick, et al.
Publicado: (2022)

In Vivo Imaging Demonstrates That Borrelia burgdorferi ospC Is Uniquely Expressed Temporally and Spatially throughout Experimental Infection
por: Skare, Jonathan T., et al.
Publicado: (2016)

Lipoprotein succession in Borrelia burgdorferi: similar but distinct roles for OspC and VlsE at different stages of mammalian infection
por: Tilly, Kit, et al.
Publicado: (2013)

Possible effect of mutations on serological detection of Borrelia burgdorferi sensu stricto ospC major groups: An in-silico study
por: Mechai, Samir, et al.
Publicado: (2023)

Structural Elucidation of a Protective B Cell Epitope on Outer Surface Protein C (OspC) of the Lyme Disease Spirochete, Borreliella burgdorferi
por: Rudolph, Michael J., et al.
Publicado: (2023)

Invasive potential of Borrelia burgdorferi sensu stricto ospC type L strains increases the possible disease risk to humans in the regions of their distribution
por: Golovchenko, Maryna, et al.
Publicado: (2014)

Genetic variation of Borreliella burgdorferi in Fairfax County, Virginia, targeting the OspC gene in white-footed mice
por: Zawada, Sonya G., et al.
Publicado: (2022)

Comparative analysis of antibody responses to outer surface protein (Osp)A and OspC in dogs vaccinated with Lyme disease vaccines
por: Camire, A.C., et al.
Publicado: (2021)

Shigella OspC3 suppresses murine cytosolic LPS sensing
por: Oh, Changhoon, et al.
Publicado: (2021)

BosR Functions as a Repressor of the ospAB Operon in Borrelia burgdorferi
por: Shi, Yanlin, et al.
Publicado: (2014)

Gac Is a Transcriptional Repressor of the Lyme Disease Spirochete’s OspC Virulence-Associated Surface Protein
por: Castro-Padovani, Tatiana N., et al.
Publicado: (2023)

Borrelia burgdorferi OspA is an arthropod-specific transmission- blocking Lyme disease vaccine
Publicado: (1996)

Immune Response to Lactobacillus plantarum Expressing Borrelia burgdorferi OspA Is Modulated by the Lipid Modification of the Antigen
por: del Rio, Beatriz, et al.
Publicado: (2010)

Blocking pathogen transmission at the source: reservoir targeted OspA-based vaccines against Borrelia burgdorferi
por: Gomes-Solecki, Maria
Publicado: (2014)

Microarray-Based Comparative Genomic and Transcriptome Analysis of Borrelia burgdorferi
por: Iyer, Radha, et al.
Publicado: (2016)

Borrelia burgdorferi and Borrelia miyamotoi seroprevalence in California blood donors
por: Brummitt, Sharon I., et al.
Publicado: (2020)

Geographic Differences in Genetic Locus Linkages for Borrelia burgdorferi
por: Travinsky, Bridgit, et al.
Publicado: (2010)

Two regulatory elements required for enhancing ospA expression in Borrelia burgdorferi grown in vitro but repressing its expression during mammalian infection
por: Xu, Qilong, et al.
Publicado: (2010)

Crystal structure of a tripartite complex between C3dg, C-terminal domains of factor H and OspE of Borrelia burgdorferi
por: Kolodziejczyk, Robert, et al.
Publicado: (2017)

Biochemical characterization of Borrelia burgdorferi’s RecA protein
por: Huang, Shu Hui, et al.
Publicado: (2017)

Experimental Infections of the Reservoir Species Peromyscus leucopus with Diverse Strains of Borrelia burgdorferi, a Lyme Disease Agent
por: Baum, Elisabeth, et al.
Publicado: (2012)

Establishment of a minor groove binder-probe based quantitative real time PCR to detect Borrelia burgdorferi sensu lato and differentiation of Borrelia spielmanii by ospA-specific conventional PCR
por: Strube, Christina, et al.
Publicado: (2010)

The Position of His-Tag in Recombinant OspC and Application of Various Adjuvants Affects the Intensity and Quality of Specific Antibody Response after Immunization of Experimental Mice
por: Krupka, Michal, et al.
Publicado: (2016)

OspA heterogeneity of Borrelia valaisiana confirmed by phenotypic and genotypic analyses
por: Ryffel, Karine, et al.
Publicado: (2003)

NMR structure of an acyl-carrier protein from Borrelia burgdorferi
por: Barnwal, Ravi P., et al.
Publicado: (2011)

Borrelia burgdorferi (Lyme Disease)
por: Shapiro, Eugene D.
Publicado: (2014)

Pathogenicity and virulence of Borrelia burgdorferi
por: Strnad, Martin, et al.
Publicado: (2023)

Borrelia burgdorferi and Borrelia miyamotoi in Atlantic Canadian wildlife
por: Zinck, Christopher B., et al.
Publicado: (2022)

Characterization of MxiE- and H-NS-Dependent Expression of ipaH7.8, ospC1, yccE, and yfdF in Shigella flexneri
por: Hall, Chelsea P., et al.
Publicado: (2022)

Molecular Characterization of Borrelia burgdorferi from Case of Autochthonous Lyme Arthritis
por: Brummitt, Sharon I., et al.
Publicado: (2014)

Borrelia burgdorferi Enolase Is a Surface-Exposed Plasminogen Binding Protein
por: Floden, Angela M., et al.
Publicado: (2011)

Characterization of the inner membrane protein BB0173 from Borrelia burgdorferi
por: Brock, Christina M., et al.
Publicado: (2017)

Borrelia burgdorferi Surface Exposed GroEL Is a Multifunctional Protein
por: Cafiero, Thomas, et al.
Publicado: (2021)

644. Borrelia miyamotoi and Borrelia burgdorferi Seroprevalence in New England
por: Johnston, Demerise, et al.
Publicado: (2020)

Borrelia burgdorferi antibodies in childhood scleroderma
por: Musiej-Nowakowska, E, et al.
Publicado: (2008)

Borrelia burgdorferi and Anaplasma phagocytophilum Coinfection
por: Loebermann, Micha, et al.
Publicado: (2006)

Cannot write session to /tmp/vufind_sessions/sess_osjhi1adok31t7ru526e44ruu6