An Experimental and Computational Evolution-Based Method to Study a Mode of Co-evolution of Overlapping Open Reading Frames in the AAV2 Viral Genome

Overlapping open reading frames (ORFs) in viral genomes undergo co-evolution; however, how individual amino acids coded by overlapping ORFs are structurally, functionally, and co-evolutionarily constrained remains difficult to address by conventional homologous sequence alignment approaches. We repo...

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Detalles Bibliográficos
Autores principales: Kawano, Yasuhiro, Neeley, Shane, Adachi, Kei, Nakai, Hiroyuki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3691236/
https://www.ncbi.nlm.nih.gov/pubmed/23826091
http://dx.doi.org/10.1371/journal.pone.0066211

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3691236/
https://www.ncbi.nlm.nih.gov/pubmed/23826091
http://dx.doi.org/10.1371/journal.pone.0066211

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