Cargando…

Low Resolution Structural Studies Indicate that the Activator of Hsp90 ATPase 1 (Aha1) of Leishmania braziliensis Has an Elongated Shape Which Allows Its Interaction with Both N- and M-Domains of Hsp90

The Hsp90 molecular chaperone is essential for protein homeostasis and in the maturation of proteins involved with cell-cycle control. The low ATPase activity of Hsp90 is critical to drive its functional cycle, which is dependent on the Hsp90 cochaperones. The Activator of Hsp90 ATPase-1 (Aha1) is a...

Descripción completa

Detalles Bibliográficos
Autores principales: Seraphim, Thiago V., Alves, Marina M., Silva, Indjara M., Gomes, Francisco E. R., Silva, Kelly P., Murta, Silvane M. F., Barbosa, Leandro R. S., Borges, Júlio C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3691308/
https://www.ncbi.nlm.nih.gov/pubmed/23826147
http://dx.doi.org/10.1371/journal.pone.0066822