Conformational changes in the catalytically inactive nucleotide-binding site of CFTR

A central step in the gating of the cystic fibrosis transmembrane conductance regulator (CFTR) chloride channel is the association of its two cytosolic nucleotide-binding domains (NBDs) into a head-to-tail dimer, with two nucleotides bound at the interface. Channel opening and closing, respectively,...

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Detalles Bibliográficos
Autores principales: Csanády, László, Mihályi, Csaba, Szollosi, Andras, Töröcsik, Beáta, Vergani, Paola
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2013
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3691448/
https://www.ncbi.nlm.nih.gov/pubmed/23752332
http://dx.doi.org/10.1085/jgp.201210954

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3691448/
https://www.ncbi.nlm.nih.gov/pubmed/23752332
http://dx.doi.org/10.1085/jgp.201210954

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